新西兰护理学代写作业:皮细胞护理

2019-03-22 05:57

第二阶段上皮细胞轻度棘皮增生和角化不全，无溃疡。炎症细胞浸润不像第一阶段那么严重。上皮下有无定形、结节状、均质、嗜酸性淀粉样堆积。累积的材料没有表现出典型的苹果绿/金棕色淀粉样蛋白与刚果红染色的双折射。硫代黄酮- t荧光法检测淀粉样蛋白也呈阴性。堆积网状不良，马森三色染色呈红色。免疫染色纤维蛋白原呈强阳性，免疫球蛋白呈弱阳性。电子显微镜下的牙龈显示出细小的丝状物，直径约10nm，排列成交织的束状，类似于木质结膜炎。在这个网络中有短束较厚、较暗的丝状体，类似上皮张力丝，也有细胞碎片。在这种材料中没有发现典型的胶原纤维。19在这些病例中，淀粉样物质没有表现出淀粉样物质的所有着色特性，其原因可以通过考虑淀粉样物质发生的过程来解释。对于像免疫球蛋白轻链和角蛋白这样的物质，为了获得淀粉样蛋白的典型特性，必须连续发生一系列与时间有关的事件。19 .如果这些阶段中有一个或多个未能发生，就可能导致一种物质的形成，而这种物质只具有淀粉样蛋白的某些特征。这种半淀粉样、半透明质材料(透明质淀粉样)需要沉积材料的更多丝状变性才能染色为典型淀粉样.
新西兰护理学代写作业:皮细胞护理
In second phase, the epithelium showed slight acanthosis and parakeratosis without ulceration. Inflammatory cell infiltrate is not as heavy as in first stage. There is subepithelial amorphous, nodular, homogeneous, eosinophilic amyloid-like accumulation. The accumulated material did not show the typical apple green/ golden brown birefringence of amyloid with Congo-red stain. Thioflavin-T fluorescence methods for demonstration of amyloid is also negative. Accumulation is reticulin poor and stained red with Masson’s trichrome stain.Immunostaining shows strongly positive for fibrinogen and weakly positive for immunoglobulins. Electron microscopy of gingiva shows fine filaments, approximately 10nm in diameter arranged in interweaving bundles resembling those seen in ligneous conjunctivitis. Within this network there are short bundles of thicker, darker filaments resembling epithelial tonofilaments and also fragments of cellular debris. No typical collagen fibers were found within this material.19The reason why the amyloid-like material in these cases failed to show all the tinctorial properties of amyloid can be explained by considering the process of amyloidogenesis. For materials like immunoglobulin light chain and keratins to acquire the typical properties of amyloid, a time-dependent series of events must occur consecutively.19 Failure of one or more of these stages to take place may conceivably result in the formation of a material which shares only some of the features of amyloid. This half-amyloid, half-hyaline material (hyaline-amyloid) needs more filamentous degeneration of the deposited materials in order to stain as typical amyloid.19

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